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Inwazja silnego i uporczywego bólu, niezależnie od jego etiologii – czy to ból ostry pooperacyjny, przewlekły ból nowotworowy, czy ból neuropatyczny – stanowi jedno z największych wyzwań dla współczesnej medycyny. W takich przypadkach, leki opioidowe, ze względu na ich niezrównaną skuteczność przeciwbólową, są często niezbęd